AUTOIMMUNE DISEASE: A VIEW OF EPIGENETICS AND THERAPEUTIC TARGETING


Identification and validation of ferroptosis-related genes and immune cell infiltration in thyroid associated ophthalmopathy

Thyroid associated ophthalmopathy (TAO) is an orbital autoimmune inflammatory disease that is commonly associated with thyroid dysfunction.Although the etiology of TAO is unclear, ROS accumulation and oxidative stress have been closely linked to the pathogenesis of TAO.Ferroptosis is an iron-dependent programmed cell death characterized by intracel

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Rhoptry Proteins ROP5 and ROP18 Are Major Murine Virulence Factors in Genetically Divergent South American Strains of Toxoplasma gondii.

Toxoplasma gondii has evolved a number of strategies to evade immune responses in its many hosts.Previous genetic mapping of crosses between clonal type 1, 2, and 3 strains of T.gondii, which are prevalent in Europe and North America, identified two rhoptry proteins, ROP5 and ROP18, that function together to block innate immune mechanisms activated

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Postposing and Information Structure in English and Farsi/Persian

The term postposing denotes any construction in which a phrasal constituent appears to the right of its canonical position, leaving its initial position either empty or occupied by an expletive.Ward and Birner (2004) argue that Hand Treatments postposed constructions preserve the old-before-new information structure paradigm in English.The present

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